
The human body can sustain a variety of injuries, including penetrating trauma, burn trauma and blunt trauma. All of these insults set into motion an orderly sequence of events that are involved in the healing response, in which the normal functional tissue (skin) is replaced by connective tissue (scar) and the healing response is characterized by the movement of specialized cells into the wound site.
Healing is the complex and dynamic process that results in the restoration of anatomical continuity and function. There are four basic responses that can occur following an injury: Normal repair (reestablished equilibrium), is the response where there is a re-established equilibrium between scar formation and scar remodeling. Excessive healing (fibrosis and contractures), there is too much deposition of connective tissue that results in altered structure and thus loss of function. Deficient healing (chronic ulcers) is the opposite of fibrosis; it exists when there is insufficient deposition of connective tissue matrix and the tissue is weakened and fragile to the point where it can bruise and bleed easily
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